Difference between revisions of "CoaA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of coenzyme A
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of coenzyme A
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU23760 coaA]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html Coenzyme A]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/CoA_synthesis.html Coenzyme A]'''

Revision as of 11:23, 7 August 2012

  • Description: probable pantothenate kinase

Gene name coaA
Synonyms yqjS
Essential no
Product probable pantothenate kinase
Function biosynthesis of coenzyme A
Gene expression levels in SubtiExpress: coaA
Metabolic function and regulation of this protein in SubtiPathways:
Coenzyme A
MW, pI 36 kDa, 5.894
Gene length, protein length 957 bp, 319 aa
Immediate neighbours yqjT, dsdA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CoaA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CoaA expression.png




























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU23760

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate (according to Swiss-Prot)
  • Protein family: prokaryotic pantothenate kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1SQ5 (from Escherichia coli, 49% identity, 67% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

W J Song, S Jackowski
Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli.
J Bacteriol: 1992, 174(20);6411-7
[PubMed:1328157] [WorldCat.org] [DOI] (P p)