Difference between revisions of "PurR"
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| − | + | * '''Description:''' transcription repressor of the pur operon <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of purine biosynthesis | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of purine biosynthesis | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PurR PurR] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/PurR PurR] | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:purR_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:purR_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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* '''Operon:''' ''[[purR]]-[[yabJ]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/7638212 PubMed] | * '''Operon:''' ''[[purR]]-[[yabJ]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/7638212 PubMed] | ||
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* '''Regulation:''' negative autoregulation, induction in the presence of PRPP [http://www.ncbi.nlm.nih.gov/sites/entrez/7638212 PubMed] | * '''Regulation:''' negative autoregulation, induction in the presence of PRPP [http://www.ncbi.nlm.nih.gov/sites/entrez/7638212 PubMed] | ||
Revision as of 10:12, 7 August 2012
- Description: transcription repressor of the pur operon
| Gene name | purR |
| Synonyms | yabI |
| Essential | no |
| Product | transcription repressor of the pur operon |
| Function | regulation of purine biosynthesis |
| Interactions involving this protein in SubtInteract: PurR | |
| Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Ala, Gly, Ser | |
| MW, pI | 31 kDa, 5.771 |
| Gene length, protein length | 855 bp, 285 aa |
| Immediate neighbours | ispE, yabJ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, transcription factors and their control
This gene is a member of the following regulons
The PurR regulon
The gene
Basic information
- Locus tag: BSU00470
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Biological activity: transcriptional repressor of purine biosynthetic operons
- Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: PRPP acts as inducer, binding results in release of PurR from the operator PubMed
Database entries
- UniProt: P37551
- KEGG entry: [3]
- E.C. number:
Additional information
requires YabJ for in vivo activity
Expression and regulation
- Regulation: negative autoregulation, induction in the presence of PRPP PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
