Difference between revisions of "MoaD"

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* '''Description:''' molybdopterin converting factor (subunit 1) <br/><br/>
+
* '''Description:''' molybdopterin synthase (small subunit) <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || molybdopterin converting factor (subunit 1)
+
|style="background:#ABCDEF;" align="center"| '''Product''' || molybdopterin synthase (small subunit)  
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || nitrate respiration  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || nitrate respiration  
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* '''Structure:'''
 
* '''Structure:'''
 +
** [http://www.rcsb.org/pdb/explore/explore.do?structureId=1NVI 1NVI] (the [[MoaD]]-[[MoaE]] complex from ''E. coli'')  {{PubMed|12571227}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O31706 O31706]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O31706 O31706]
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
+
* '''Operon:''' ''[[mobA]]-[[moeB]]-[[moeA]]-[[mobB]]-[[moaE]]-[[moaD]]'' {{PubMed|22383849}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=moaD_1499432_1499665_1 moaD] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=moaD_1499432_1499665_1 moaD] {{PubMed|22383849}}
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=References=
 
=References=
 
+
== Reviews ==
 +
<pubmed> 22616866 </pubmed>
 +
== Original publications ==
 +
<pubmed> 12571227 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 14:34, 4 June 2012

  • Description: molybdopterin synthase (small subunit)

Gene name moaD
Synonyms
Essential no
Product molybdopterin synthase (small subunit)
Function nitrate respiration
MW, pI 7 kDa, 3.829
Gene length, protein length 231 bp, 77 aa
Immediate neighbours moaE, yknU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MoaD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MoaD expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU14310

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Tadhg P Begley, Steven E Ealick, Fred W McLafferty
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Biochem Soc Trans: 2012, 40(3);555-60
[PubMed:22616866] [WorldCat.org] [DOI] (I p)

Original publications

Michael J Rudolph, Margot M Wuebbens, Oliver Turque, K V Rajagopalan, Hermann Schindelin
Structural studies of molybdopterin synthase provide insights into its catalytic mechanism.
J Biol Chem: 2003, 278(16);14514-22
[PubMed:12571227] [WorldCat.org] [DOI] (P p)