NadB

• Description: L-aspartate oxidase
  
  

Gene name	nadB
Synonyms
Essential	no
Product	L-aspartate oxidase
Function	NAD biosynthesis
MW, pI	58 kDa, 6.445
Gene length, protein length	1593 bp, 531 aa
Immediate neighbours	nadC, nifS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

NadR regulon

The gene

Basic information

• Locus tag: BSU27870

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-aspartate + O₂ = iminosuccinate + H₂O₂ (according to Swiss-Prot)

• Protein family: NadB subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P38032

• KEGG entry: [3]

• E.C. number: 1.4.3.16

Expression and regulation

• Operon: nadB-nadC-nadA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of nicotinic acid (NadR) PubMed

• Regulatory mechanism:
  • NadR: transcription repression PubMed

• Additional information:
  • An antisense RNA is predicted for nadB PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Alessandra Albertini, University of Pavia, Italy homepage