Difference between revisions of "FadR"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 
** induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}}
 
** induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}}
 +
** subject to carbon catabolite repression ([[CcpA]]-[[PtsH|HPr(Ser-P)]] {{PubMed|21398533}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[FadR]]: transcription repression {{PubMed|17189250}}
 
** [[FadR]]: transcription repression {{PubMed|17189250}}
 +
** [[CcpA]]-[[PtsH|HPr(Ser-P)]]: transcription repression {{PubMed|21398533}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
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<pubmed>17919287,</pubmed>
 
<pubmed>17919287,</pubmed>
 
==Original publications==
 
==Original publications==
 +
'''Additional publications:''' {{PubMed|21398533}}
 
<pubmed>17189250,</pubmed>
 
<pubmed>17189250,</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:52, 19 March 2011

  • Description: transcriptional repressor (TetR family), regulation of fatty acid degradation

Gene name fadR
Synonyms ysiA
Essential no
Product transcriptional repressor
Function regulation of fatty acid degradation
Metabolic function and regulation of this protein in SubtiPathways:
Fatty acid degradation
MW, pI 21 kDa, 6.118
Gene length, protein length 582 bp, 194 aa
Immediate neighbours fadB, lcfA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YsiA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of lipids, transcription factors and their control

This gene is a member of the following regulons

FadR regulon

The FadR regulon

The gene

Basic information

  • Locus tag: BSU28550

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: long chain fatty acids act as inducers that release FadR from its operator sites
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications

Additional publications: PubMed

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)