Difference between revisions of "FadE"

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* '''Operon:'''  
 
* '''Operon:'''  
 +
** ''[[fadM]]-[[fadN]]-[[fadA]]-[[fadE]]'' {{PubMed|17189250}}
 +
** ''[[fadN]]-[[fadA]]-[[fadE]]'' {{PubMed|17189250}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
 +
** ''[[fadN]]'': [[SigA]] {{PubMed|17189250}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** repressed in the absence of long-chain fatty acids ([[FadR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17189250 PubMed]
+
** ''[[fadN]]'': induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
** [[FadR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/17189250 PubMed]
+
** [[FadR]]: transcription repression {{PubMed|17189250}}
 +
** [[SdpR]]: transcription activation {{PubMed|12817086}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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=References=
 
=References=
  
<pubmed>17189250,,17189250,17189250, </pubmed>
+
<pubmed>17189250,12817086 ,</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 16:26, 28 December 2009

  • Description: acyl-CoA dehydrogenase

Gene name fadE
Synonyms yusJ
Essential no
Product acyl-CoA dehydrogenase
Function fatty acid degradation
MW, pI 65 kDa, 5.146
Gene length, protein length 1782 bp, 594 aa
Immediate neighbours yusI, fadA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YusJ context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU32820

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF (according to Swiss-Prot)
  • Protein family: acyl-CoA dehydrogenase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)