Difference between revisions of "MmgA"
| Line 90: | Line 90: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' [[mmgA]]-[[mmgB]]-[[mmgC]]-[[mmgD]]-[[mmgE]]-[[yqiQ]] {{PubMed|8759838}} |
| − | * '''[[Sigma factor]]:''' [[SigE]] {{PubMed|15699190}} | + | * '''[[Sigma factor]]:''' [[SigE]] {{PubMed|15699190,8759838}} |
| − | * '''Regulation:''' repressed by glucose ([[CcpA]]) | + | * '''Regulation:''' |
| + | ** expressed early during sporulation in the mother cell ([[SigE]]) {{PubMed|15699190,8759838}} | ||
| + | ** repressed by glucose ([[CcpA]]) {{PubMed|8759838}} | ||
| − | * '''Regulatory mechanism:''' [[CcpA]]: transcription repression | + | * '''Regulatory mechanism:''' |
| + | **[[CcpA]]: transcription repression {{PubMed|8759838}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 120: | Line 123: | ||
=References= | =References= | ||
| − | <pubmed>18246303,8759838,, </pubmed> | + | <pubmed>18246303,8759838,15699190, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:42, 20 November 2009
- Description: degradative acetoacetyl-CoA thiolase
| Gene name | mmgA |
| Synonyms | yqiL |
| Essential | no |
| Product | degradative acetoacetyl-CoA thiolase |
| Function | mother cell metabolism |
| Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism | |
| MW, pI | 41 kDa, 5.904 |
| Gene length, protein length | 1179 bp, 393 aa |
| Immediate neighbours | mmgB, yqiK |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU24170
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 2 acetyl-CoA = CoA + acetoacetyl-CoA (according to Swiss-Prot)
- Protein family: thiolase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P45855
- KEGG entry: [3]
- E.C. number: 2.3.1.9
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jason J Reddick, Jayme K Williams
The mmgA gene from Bacillus subtilis encodes a degradative acetoacetyl-CoA thiolase.
Biotechnol Lett: 2008, 30(6);1045-50
[PubMed:18246303]
[WorldCat.org]
[DOI]
(P p)
Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190]
[WorldCat.org]
[DOI]
(P p)
E M Bryan, B W Beall, C P Moran
A sigma E dependent operon subject to catabolite repression during sporulation in Bacillus subtilis.
J Bacteriol: 1996, 178(16);4778-86
[PubMed:8759838]
[WorldCat.org]
[DOI]
(P p)
