Difference between revisions of "CotC"

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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
+
* '''Operon:''' ''cotC'' (according to [http://dbtbs.hgc.jp/COG/prom/cotC.html DBTBS])
  
* '''[[Sigma factor]]:'''  
+
* '''[[Sigma factor]]:''' [[SigK]] {{PubMed|1518043}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** expressed late during sporulation in the mother cell ([[SigK]], [[GerE]], [[SpoIIID]]) {{PubMed|1518043,10788508}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[GerE]]: transcription activation {{PubMed|1518043}}
 +
** [[SpoIIID]]: transcription repression {{PubMed|10788508}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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=References=
 
=References=
  
<pubmed>,1518043,2821284,12031481,1691789,18065538 </pubmed>
+
<pubmed>,1518043,2821284,12031481,1691789,18065538 10788508 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 12:03, 18 October 2009

  • Description: spore coat protein (outer)

Gene name cotC
Synonyms
Essential no
Product spore coat protein (outer)
Function resistance of the spore
MW, pI 14 kDa, 9.558
Gene length, protein length 354 bp, 118 aa
Immediate neighbours yncM, tatAC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CotC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU17700

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: cotC (according to DBTBS)
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Rachele Isticato, Assunta Pelosi, Rita Zilhão, Loredana Baccigalupi, Adriano O Henriques, Maurilio De Felice, Ezio Ricca
CotC-CotU heterodimerization during assembly of the Bacillus subtilis spore coat.
J Bacteriol: 2008, 190(4);1267-75
[PubMed:18065538] [WorldCat.org] [DOI] (I p)

Dinene L Crater, Kathryn H Wade, Orna Resnekov, H Travis Ichikawa, Lee Kroos, James A Brannigan, Charles P Moran
A mutation in GerE that affects cotC promoter activation in Bacillus subtilis.
Biochim Biophys Acta: 2002, 1576(1-2);30-8
[PubMed:12031481] [WorldCat.org] [DOI] (P p)

H Ichikawa, L Kroos
Combined action of two transcription factors regulates genes encoding spore coat proteins of Bacillus subtilis.
J Biol Chem: 2000, 275(18);13849-55
[PubMed:10788508] [WorldCat.org] [DOI] (P p)

L Zheng, R Halberg, S Roels, H Ichikawa, L Kroos, R Losick
Sporulation regulatory protein GerE from Bacillus subtilis binds to and can activate or repress transcription from promoters for mother-cell-specific genes.
J Mol Biol: 1992, 226(4);1037-50
[PubMed:1518043] [WorldCat.org] [DOI] (P p)

L B Zheng, R Losick
Cascade regulation of spore coat gene expression in Bacillus subtilis.
J Mol Biol: 1990, 212(4);645-60
[PubMed:1691789] [WorldCat.org] [DOI] (P p)

W Donovan, L B Zheng, K Sandman, R Losick
Genes encoding spore coat polypeptides from Bacillus subtilis.
J Mol Biol: 1987, 196(1);1-10
[PubMed:2821284] [WorldCat.org] [DOI] (P p)