Difference between revisions of "Tpi"

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(Database entries)
(Database entries)
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=== Database entries ===
 
=== Database entries ===
  
* '''Structure:''' [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=48255 NCBI]
+
* '''Structure:''' complex with 2-phosphpoglycolic acid, ''Geobacillus stearothermophilus'' [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=48255 NCBI]
  
 
* '''Swiss prot entry:''' [http://www.expasy.ch/cgi-bin/sprot-search-ac?P27876]
 
* '''Swiss prot entry:''' [http://www.expasy.ch/cgi-bin/sprot-search-ac?P27876]

Revision as of 12:42, 8 January 2009

  • Description: catalyzes the transformation of glycerinaldehyd 3-phosphate to dihydroxyactonphosphate and the reverse reaktion

Gene name tpi
Synonyms tpiA
Essential yes
Product Triosephosphate isomerase
Function isomerase
MW, pI 26,9 kDa, 4.79
Gene length, protein length 759 bp, 253 amino acids
Immediate neighbours pgk, pgm
Gene sequence (+200bp) Protein sequence
Genetic context
File:GenE context.gif












The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-glyceraldehyde 3-phosphate = glycerone phosphate
  • Protein family: triosephosphate isomerase family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions: Pgm-TpiA
  • Localization: Cytoplasm PubMed

Database entries

  • Structure: complex with 2-phosphpoglycolic acid, Geobacillus stearothermophilus NCBI
  • Swiss prot entry: [3]
  • KEGG entry: [4]
  • E.C. number: [5]

Additional information

Expression and regulation

  • Regulation: neg. regulated by CggR, induced by sugar
  • Regulatory mechanism: repressor CggR
  • Additional information:

Biological materials

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed