Difference between revisions of "IolA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || myo-inositol catabolism
 
|style="background:#ABCDEF;" align="center"|'''Function''' || myo-inositol catabolism
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 53 kDa, 5.139   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 53 kDa, 5.139   

Revision as of 11:50, 11 June 2009

  • Description: methylmalonate-semialdehyde dehydrogenase (acylating)

Gene name iolA
Synonyms mmsA, yxdA
Essential no
Product methylmalonate-semialdehyde dehydrogenase (acylating)
Function myo-inositol catabolism
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 53 kDa, 5.139
Gene length, protein length 1461 bp, 487 aa
Immediate neighbours iolB, iolR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MmsA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU39760

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H (according to Swiss-Prot)
  • Protein family: IolA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ken-ichi Yoshida, Masanori Yamaguchi, Tetsuro Morinaga, Masaki Kinehara, Maya Ikeuchi, Hitoshi Ashida, Yasutaro Fujita
myo-Inositol catabolism in Bacillus subtilis.
J Biol Chem: 2008, 283(16);10415-24
[PubMed:18310071] [WorldCat.org] [DOI] (P p)


  1. Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y. (2008) myo-Inositol catabolism in Bacillus subtilis. J Biol Chem. Apr 18;283(16): 10415-24. PubMed