Difference between revisions of "SirA"

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* '''Description:''' unknown <br/><br/>
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* '''Description:''' sporulation protein, inhibits DNA replication <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
+
|style="background:#ABCDEF;" align="center"| '''Product''' || inhibitor of DNA replication
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
+
|style="background:#ABCDEF;" align="center"|'''Function''' || control of chromosome copy number
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 7.353   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 7.353   

Revision as of 11:54, 7 April 2009

  • Description: sporulation protein, inhibits DNA replication

Gene name sirA
Synonyms yneE, yoxF
Essential no
Product inhibitor of DNA replication
Function control of chromosome copy number
MW, pI 17 kDa, 7.353
Gene length, protein length 444 bp, 148 aa
Immediate neighbours tkt, yneF
Gene sequence (+200bp) Protein sequence
Genetic context
YneE context.gif
This image was kindly provided by SubtiList



The gene

yneE was renamed to sirA.

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

sirA (sporulation inhibitor of replication) is activated by Spo0A~P and inhibits DNA replication during sporulation.

References

  1. Rahn-Lee L, Gorbatyuk B, Skovgaard O & Losick R.(2009) The Conserved Sporulation Protein YneE inhibits DNA replication in Bacillus subtilis J Bact. volume: page-page. PubMed