Difference between revisions of "Metabolism of signalling nucleotides"

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* [[PgpH]]
 
* [[PgpH]]
  
===c-di-GMP degradation (presence of an EAL domain)===
+
===Protein potentially involved in c-di-GMP metabolism and signalling==
 +
 
 +
==== Proteins containing a GGDEF domain (potential diguanylate cyclases) ====
 +
* [[DgcK]], has cyclase activity
 +
* [[DgcW]], has cyclase activity, contains both a GGDEF and an EAL domain
 +
* [[DgcP]], has cyclase activity
 +
* [[YdaK]], no activity, modified GGDEF domain
 +
* [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), modified GGDEF domain
 +
 
 +
==== Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases) ====
 
* [[DgcW]] (not experimentally proven)
 
* [[DgcW]] (not experimentally proven)
 
* [[PdeH]]
 
* [[PdeH]]
  
=== c-di-GMP synthesis ===
 
* [[DgcK]]
 
* [[DgcW]]
 
* [[DgcP]]
 
  
 
=== Targets of signalling nucleotides ===
 
=== Targets of signalling nucleotides ===

Revision as of 09:41, 5 July 2016

Parent categories
Neighbouring categories
Related categories

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

Control of c-di-AMP synthesis

Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed

c-di-AMP degradation

=Protein potentially involved in c-di-GMP metabolism and signalling

Proteins containing a GGDEF domain (potential diguanylate cyclases)

  • DgcK, has cyclase activity
  • DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
  • DgcP, has cyclase activity
  • YdaK, no activity, modified GGDEF domain
  • GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), modified GGDEF domain

Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)


Targets of signalling nucleotides

  • c-di-GMP targets
    • DgrA (contains a PilZ domain)
  • other c-di-GMP-binding proteins

Important original publications


Important reviews


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