SdpR

• Description: transcriptional repressor of the sdpR-sdpI operon
  
  

Gene name	sdpR
Synonyms	yvbA
Essential	no
Product	transcriptional regulator (ArsR family)
Function	regulation of protection against SdpC
Gene expression levels in SubtiExpress: sdpR
Interactions involving this protein in SubtInteract: SdpR
MW, pI	10 kDa, 7.328
Gene length, protein length	270 bp, 90 aa
Immediate neighbours	sdpI, opuCD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

AbrB regulon, SdpR regulon

The SdpR regulon:

• fadM-fadN-fadA-fadE, sdpR-sdpI

The gene

Basic information

• Locus tag: BSU33790

Database entries

• BsubCyc: BSU33790

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: SdpI binds and sequesters SdpR if extracellular SdpC is present, this results in induction of the sdpR-sdpI operon PubMed

• Interactions:
  • SdpI-SdpR PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33790

• Structure:

• UniProt: O32242

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sdpR-sdpI PubMed

• Expression browser: sdpR PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during logrithmic growth (AbrB) PubMed
  • induced by extracellular SdpC (SdpR) PubMed

• Regulatory mechanism:
  • AbrB: transcription repression PubMed
  • SdpR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)

Original Publications

Craig D Ellermeier, Errett C Hobbs, Jose E Gonzalez-Pastor, Richard Losick
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.
Cell: 2006, 124(3);549-59
[PubMed:16469701] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)

M S Turner, J D Helmann
Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis.
J Bacteriol: 2000, 182(18);5202-10
[PubMed:10960106] [WorldCat.org] [DOI] (P p)