Difference between revisions of "Ldh"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Ldh Ldh]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Ldh Ldh]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=ldh ldh]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 5.394   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 5.394   

Revision as of 10:06, 7 January 2014

  • Description: L-lactate dehydrogenase

Gene name ldh
Synonyms lctE
Essential no
Product L-lactate dehydrogenase
Function overflow metabolism, fermentation
Gene expression levels in SubtiExpress: ldh
Interactions involving this protein in SubtInteract: Ldh
Metabolic function and regulation of this protein in SubtiPathways:
ldh
MW, pI 34 kDa, 5.394
Gene length, protein length 963 bp, 321 aa
Immediate neighbours amyE, lctP
Sequences Protein DNA DNA_with_flanks
Genetic context
Ldh context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ldh expression.png




























Categories containing this gene/protein

carbon core metabolism, phosphoproteins

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

  • Locus tag: BSU03050

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-lactate + NAD+ = pyruvate + NADH (according to Swiss-Prot)
  • Protein family: LDH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Tyr-224 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced under anaerobic conditions (Rex) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional references: PubMed