Difference between revisions of "FolC"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28080 folC]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28080 folC]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/tRNA_charging.html tRNA charging], [http://subtiwiki.uni-goettingen.de/pathways/folate_biosynthesis.html Folate]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=folC folC]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 48 kDa, 5.806   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 48 kDa, 5.806   

Revision as of 11:22, 7 January 2014

  • Description: folyl-polyglutamate synthetase

Gene name folC
Synonyms
Essential no
Product folyl-polyglutamate synthetase
Function biosynthesis of folate
Gene expression levels in SubtiExpress: folC
Metabolic function and regulation of this protein in SubtiPathways:
folC
MW, pI 48 kDa, 5.806
Gene length, protein length 1290 bp, 430 aa
Immediate neighbours comC, valS
Sequences Protein DNA DNA_with_flanks
Genetic context
FolC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FolC expression.png




























Categories containing this gene/protein

biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

T-box

The gene

Basic information

  • Locus tag: BSU28080

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)
  • Protein family: folylpolyglutamate synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1FGS (from Lactobacillus casei, 32% identity, 51% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532] [WorldCat.org] [DOI] (I p)

Original Publications