Difference between revisions of "PksC"

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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
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* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
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* '''Operon:''' [[pksC]]-[[pksD]]-[[pksE]]-[[acpK]]-[[pksF]]-[[pksG]]-[[pksH]]-[[pksI]]-[[pskJ]]-[[pksL]]-[[pksM]]-[[pksN]]-[[pksR]] {{PubMed|22383849}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pksC_1783763_1784629_1 pksC] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pksC_1783763_1784629_1 pksC] {{PubMed|22383849}}
  
* '''Sigma factor:'''  
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* '''[[Sigma factor]]:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** expressed during the transition from growth to stationary phase ([[AbrB]], [[CodY]]) {{PubMed|24187085}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
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** [[AbrB]]: transcription repression {{PubMed|24187085}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
 +
** this is a very large operon comprising about 75 kb
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
'''Additional publications:''' {{PubMed|21505242}}
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<pubmed>22383849 21505242 24187085</pubmed>  
<pubmed></pubmed>  
 
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 16:17, 17 December 2013

  • Description: bacillaene synthase trans-acting acyltransferase

Gene name pksC
Synonyms
Essential no
Product bacillaene synthase trans-acting acyltransferase
Function polyketide (bacillaene) synthesis
Gene expression levels in SubtiExpress: pksC
MW, pI 32 kDa, 5.328
Gene length, protein length 864 bp, 288 aa
Immediate neighbours pksB, pksD
Sequences Protein DNA DNA_with_flanks
Genetic context
PksC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PksC expression.png















Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU17100

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed during the transition from growth to stationary phase (AbrB, CodY) PubMed
  • Regulatory mechanism:
  • Additional information:
    • this is a very large operon comprising about 75 kb

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Carol Vargas-Bautista, Kathryn Rahlwes, Paul Straight
Bacterial competition reveals differential regulation of the pks genes by Bacillus subtilis.
J Bacteriol: 2014, 196(4);717-28
[PubMed:24187085] [WorldCat.org] [DOI] (I p)

Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849] [WorldCat.org] [DOI] (I p)

Fiona Cuskin, Alexandra S Solovyova, Richard J Lewis, Paul R Race
Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2011, 67(Pt 4);464-6
[PubMed:21505242] [WorldCat.org] [DOI] (I p)