Difference between revisions of "SrtN"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU09650&redirect=T BSU09650] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU09650&redirect=T BSU09650] | ||
* '''Structure:''' | * '''Structure:''' | ||
Revision as of 13:18, 2 April 2014
- Description: protein deacetylase for the control of AcsA activity
| Gene name | srtN |
| Synonyms | yhdZ |
| Essential | no |
| Product | NAD(+)-dependent AcsA deacetylase |
| Function | control of AcsA activity |
| Gene expression levels in SubtiExpress: srtN | |
| MW, pI | 27 kDa, 5.134 |
| Gene length, protein length | 741 bp, 247 aa |
| Immediate neighbours | yhdY, yheN |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU09650
Phenotypes of a mutant
Database entries
- BsubCyc: BSU09650
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein (according to Swiss-Prot) deacetylates (and thereby activates) AcsA (together with AcuC) PubMed
- Protein family: deacetylase sirtuin-type domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU09650
- Structure:
- UniProt: O07595
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- GP1210 (srtN::cat), available in Jörg Stülke's lab
- 1A888 ( srtN::spec), PubMed, available at BGSC
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jeffrey G Gardner, Jorge C Escalante-Semerena
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase.
J Bacteriol: 2009, 191(6);1749-55
[PubMed:19136592]
[WorldCat.org]
[DOI]
(I p)
