Difference between revisions of "FolC"

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Revision as of 14:10, 16 May 2013

  • Description: folyl-polyglutamate synthetase

Gene name folC
Synonyms
Essential no
Product folyl-polyglutamate synthetase
Function biosynthesis of folate
Gene expression levels in SubtiExpress: folC
Metabolic function and regulation of this protein in SubtiPathways:
tRNA charging, Folate
MW, pI 48 kDa, 5.806
Gene length, protein length 1290 bp, 430 aa
Immediate neighbours comC, valS
Sequences Protein DNA DNA_with_flanks
Genetic context
FolC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FolC expression.png




























Categories containing this gene/protein

biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

T-box

The gene

Basic information

  • Locus tag: BSU28080

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)
  • Protein family: folylpolyglutamate synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1FGS (from Lactobacillus casei, 32% identity, 51% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications

D Luo, J Leautey, M Grunberg-Manago, H Putzer
Structure and regulation of expression of the Bacillus subtilis valyl-tRNA synthetase gene.
J Bacteriol: 1997, 179(8);2472-8
[PubMed:9098041] [WorldCat.org] [DOI] (P p)