Difference between revisions of "KinA"
| Line 87: | Line 87: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' C-terminal histidine phosphotransferase domain | + | * '''Domains:''' |
| + | ** three tandem PAS domains in the N-terminal region of KinA, the second PAS domain is the major N-terminal determinant of KinA dimerization {{PubMed|23504013}} | ||
| + | ** C-terminal histidine phosphotransferase domain | ||
* '''Modification:''' autophosphorylation on a His residue | * '''Modification:''' autophosphorylation on a His residue | ||
| Line 156: | Line 158: | ||
<pubmed>22303284 </pubmed> | <pubmed>22303284 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | + | <pubmed>23169620 20511506 19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 23504013 </pubmed> | |
| − | <pubmed>20511506 19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:20, 27 March 2013
- Description: two-component sensor kinase, phosphorylates Spo0F, part of the phosphorelay
| Gene name | kinA |
| Synonyms | spoIIF, spoIIJ, gsiC, scoB, scoD |
| Essential | no |
| Product | two-component sensor kinase |
| Function | initiation of sporulation |
| Gene expression levels in SubtiExpress: kinA | |
| Interactions involving this protein in SubtInteract: KinA | |
| Function and regulation of this protein in SubtiPathways: Phosphorelay | |
| MW, pI | 68 kDa, 5.491 |
| Gene length, protein length | 1818 bp, 606 aa |
| Immediate neighbours | pbpH, patA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, phosphorelay, phosphoproteins
This gene is a member of the following regulons
SigH regulon, Spo0A regulon, stringent response
The gene
Basic information
- Locus tag: BSU13990
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- three tandem PAS domains in the N-terminal region of KinA, the second PAS domain is the major N-terminal determinant of KinA dimerization PubMed
- C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2VLG (PAS domain)
- UniProt: P16497
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- expressed under conditions that trigger sporulation (Spo0A) PubMed
- induced upon addition of decoyinine (positive stringent response) PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Liza Gross
Built-in timer delays differentiation.
PLoS Biol: 2012, 10(1);e1001254
[PubMed:22303284]
[WorldCat.org]
[DOI]
(I p)
Original Publications
