Difference between revisions of "KinA"
| Line 49: | Line 49: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
{{SubtiWiki regulon|[[SigH regulon]]}}, | {{SubtiWiki regulon|[[SigH regulon]]}}, | ||
| − | {{SubtiWiki regulon|[[Spo0A regulon]]}} | + | {{SubtiWiki regulon|[[Spo0A regulon]]}}, |
| + | {{SubtiWiki regulon|[[stringent response]]}} | ||
=The gene= | =The gene= | ||
| Line 92: | Line 93: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' interaction with [[KipI]] or [[Sda]] inhibits autophosphorylation of [[KinA]] {{PubMed|9334321,15023339}} | + | * '''Effectors of protein activity:''' |
| + | ** interaction with [[KipI]] or [[Sda]] inhibits autophosphorylation of [[KinA]] {{PubMed|9334321,15023339}} | ||
| + | ** autophosphorylation is inhibited by [[SivA]] and [[BslA]] {{PubMed|23335417}} | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| Line 120: | Line 123: | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 kinA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinA_1470026_1471846_1 kinA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigH]] {{PubMed|1569009}} | + | * '''[[Sigma factor]]:''' [[SigH]] {{PubMed|1569009}} |
* '''Regulation:''' | * '''Regulation:''' | ||
** expressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|9644251}} | ** expressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|9644251}} | ||
| + | ** induced upon addition of decoyinine (positive [[stringent response]]) {{PubMed|23378509}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 153: | Line 157: | ||
==Original Publications== | ==Original Publications== | ||
'''Additional original publications:''' {{PubMed|23169620}} | '''Additional original publications:''' {{PubMed|23169620}} | ||
| − | <pubmed>20511506 19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 </pubmed> | + | <pubmed>20511506 19561131, 20413551 1846779,11292798,16166384, 11734624,9299348,12067336,18174125, 10094672, 11069677,15023339,2509430, 17350039 ,9334321,9477965,9644251, 1569009 20081035 21097618 21926229 22303282 22670053 23335417 23378509 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:30, 5 February 2013
- Description: two-component sensor kinase, phosphorylates Spo0F, part of the phosphorelay
| Gene name | kinA |
| Synonyms | spoIIF, spoIIJ, gsiC, scoB, scoD |
| Essential | no |
| Product | two-component sensor kinase |
| Function | initiation of sporulation |
| Gene expression levels in SubtiExpress: kinA | |
| Interactions involving this protein in SubtInteract: KinA | |
| Function and regulation of this protein in SubtiPathways: Phosphorelay | |
| MW, pI | 68 kDa, 5.491 |
| Gene length, protein length | 1818 bp, 606 aa |
| Immediate neighbours | pbpH, patA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, phosphorelay, phosphoproteins
This gene is a member of the following regulons
SigH regulon, Spo0A regulon, stringent response
The gene
Basic information
- Locus tag: BSU13990
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 2VLG (PAS domain)
- UniProt: P16497
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- expressed under conditions that trigger sporulation (Spo0A) PubMed
- induced upon addition of decoyinine (positive stringent response) PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Liza Gross
Built-in timer delays differentiation.
PLoS Biol: 2012, 10(1);e1001254
[PubMed:22303284]
[WorldCat.org]
[DOI]
(I p)
Original Publications
Additional original publications: PubMed
