Difference between revisions of "DegU"

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= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
 +
{{SubtiWiki regulon|[[CcpA regulon]]}},
 
{{SubtiWiki regulon|[[DegU regulon]]}},
 
{{SubtiWiki regulon|[[DegU regulon]]}},
 
{{SubtiWiki regulon|[[TnrA regulon]]}}
 
{{SubtiWiki regulon|[[TnrA regulon]]}}
 +
 
=The [[DegU regulon]]=
 
=The [[DegU regulon]]=
 
=The gene=
 
=The gene=
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* '''Regulation:'''  
 
* '''Regulation:'''  
 
** induced in the presence of ammonium ([[TnrA]]) {{PubMed|18502860}}
 
** induced in the presence of ammonium ([[TnrA]]) {{PubMed|18502860}}
 +
** induced by glucose ([[CcpA]]) {{PubMed|23123903}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[DegU]]: positive autoregulation {{PubMed|18502860}}
 
** [[DegU]]: positive autoregulation {{PubMed|18502860}}
 
** [[TnrA]]: transcription repression {{PubMed|18502860}}
 
** [[TnrA]]: transcription repression {{PubMed|18502860}}
 +
** [[CcpA]]: transcription activation {{PubMed|23123903}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
Line 157: Line 161:
 
==Original Publications==
 
==Original Publications==
 
'''Additional publications:''' {{PubMed|21965392}}
 
'''Additional publications:''' {{PubMed|21965392}}
<pubmed>17850253,8878039, 14563871,1901568,1321152,1459944, 18194340 18978066 10908654,18502860,10094672,19389763, 20815827 21742882 18414485,19420703,2428811, 7746142, 18502860, 19389763, 19416356, 19734658 1688843 20070525 18197985 15598897 12950930 17590234 8955341 22496484 22745669 </pubmed>
+
<pubmed>17850253,8878039, 14563871,1901568,1321152,1459944, 18194340 18978066 10908654,18502860,10094672,19389763, 20815827 21742882 18414485,19420703,2428811, 7746142, 18502860, 19389763, 19416356, 19734658 1688843 20070525 18197985 15598897 12950930 17590234 8955341 22496484 22745669 23123903 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:48, 12 November 2012

  • Description: two-component response regulator, regulation of degradative enzyme and genetic competence, involved in activation of capsule biosynthetic operon expression (together with SwrAA), non-phosphorylated DegU is required for swarming motility PubMed

Gene name degU
Synonyms sacU, iep
Essential no
Product two-component response regulator
Function regulation of degradative enzyme and genetic competence
Gene expression levels in SubtiExpress: degU
Interactions involving this protein in SubtInteract: DegU
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 25 kDa, 5.602
Gene length, protein length 687 bp, 229 aa
Immediate neighbours yviA, degS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
DegU context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DegU expression.png















Categories containing this gene/protein

biofilm formation, transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, DegU regulon, TnrA regulon

The DegU regulon

The gene

Basic information

  • Locus tag: BSU35490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activator of degradative enzyme genes (sacB and degQ) and of comK expression
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated by DegS on Asp-56 PubMed, this modulates DNA-binding activity
  • Cofactor(s):

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

The DegU regulon

U Mäder, H Antelmann, T Buder, M K Dahl, M Hecker, G Homuth
Bacillus subtilis functional genomics: genome-wide analysis of the DegS-DegU regulon by transcriptomics and proteomics.
Mol Genet Genomics: 2002, 268(4);455-67
[PubMed:12471443] [WorldCat.org] [DOI] (P p)

Original Publications

Additional publications: PubMed