Difference between revisions of "Fra"
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|style="background:#ABCDEF;" align="center"|'''Function''' || intracellular iron channeling, biosynthesis of iron-sulfur clusters | |style="background:#ABCDEF;" align="center"|'''Function''' || intracellular iron channeling, biosynthesis of iron-sulfur clusters | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU05750 fra] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Fra Fra] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/Fra Fra] | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[phoB]]'', ''[[ydhH]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[phoB]]'', ''[[ydhH]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU05750 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU05750 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU05750 Advanced_DNA] |
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|colspan="2" | '''Genetic context''' <br/> [[Image:ydhG_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ydhG_context.gif]] | ||
Revision as of 12:15, 13 May 2013
- Description: frataxin-like protein, required for the biosynthesis of iron-sulfur clusters
| Gene name | fra |
| Synonyms | ydhG |
| Essential | no |
| Product | frataxin-like protein |
| Function | intracellular iron channeling, biosynthesis of iron-sulfur clusters |
| Gene expression levels in SubtiExpress: fra | |
| Interactions involving this protein in SubtInteract: Fra | |
| MW, pI | 14 kDa, 5.377 |
| Gene length, protein length | 369 bp, 123 aa |
| Immediate neighbours | phoB, ydhH |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU05750
Phenotypes of a mutant
- severe growth phenotype associated with a broadly disturbed iron homeostasis PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transfers iron onto the B. subtilis SUF system (SufU-SufS) for iron-sulfur cluster biosynthesis PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): Fe(2+) is bound with high affinity PubMed
- Effectors of protein activity:
Database entries
- Structure: 2OC6
- UniProt: Q797E6
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: available in Mohamed Marahiel's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Wenbin Qi, J A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chem Commun (Camb): 2010, 46(5);719-21
[PubMed:20087498]
[WorldCat.org]
[DOI]
(I p)
