Difference between revisions of "NtdB"

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* '''Description:''' synthesis of the antibiotic neotrehalosadiamine <br/><br/>
+
* '''Description:''' kanosamine-6-phosphate phosphatase <br/><br/>
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
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|style="background:#ABCDEF;" align="center"| '''Product''' || kanosamine-6-phosphate phosphatase
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || synthesis of the antibiotic neotrehalosadiamine
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|style="background:#ABCDEF;" align="center"|'''Function''' || synthesis of the antibiotic kanosamine
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU10540 ntdB]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU10540 ntdB]
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
 +
** kanosamine-6-phosphate --> kanosamine {{PubMed|23586652}}
  
 
* '''Protein family:''' Cof family (according to Swiss-Prot)
 
* '''Protein family:''' Cof family (according to Swiss-Prot)
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ntdB_1127466_1128314_-1 ntdB] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ntdB_1127466_1128314_-1 ntdB] {{PubMed|22383849}}
  
* '''Sigma factor:''' [[SigA]] {{PubMed|14612444}}
+
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|14612444}}
  
 
* '''Regulation:''' induced by 3,3'-neotrehalosadiamine ([[NtdR]]) {{PubMed|14612444}}
 
* '''Regulation:''' induced by 3,3'-neotrehalosadiamine ([[NtdR]]) {{PubMed|14612444}}
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<pubmed> 21512256</pubmed>
 
<pubmed> 21512256</pubmed>
 
==Original publications==
 
==Original publications==
<pubmed>19087206,17056753 ,14612444 </pubmed>
+
<pubmed>19087206,17056753 ,14612444 23586652 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 13:37, 19 April 2013

  • Description: kanosamine-6-phosphate phosphatase

Gene name ntdB
Synonyms yhjK
Essential no
Product kanosamine-6-phosphate phosphatase
Function synthesis of the antibiotic kanosamine
Gene expression levels in SubtiExpress: ntdB
MW, pI 33 kDa, 5.352
Gene length, protein length 858 bp, 286 aa
Immediate neighbours ntdC, ntdA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YhjK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NtdB expression.png















Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

NtdR regulon

The gene

Basic information

  • Locus tag: BSU10540

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • kanosamine-6-phosphate --> kanosamine PubMed
  • Protein family: Cof family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by 3,3'-neotrehalosadiamine (NtdR) PubMed
  • Regulatory mechanism: NtdR: positive regulator PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Takashi Inaoka, Kozo Ochi
Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.
Biosci Biotechnol Biochem: 2011, 75(4);618-23
[PubMed:21512256] [WorldCat.org] [DOI] (I p)

Original publications