Difference between revisions of "NadA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || NAD biosynthesis  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || NAD biosynthesis  
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU27850 nadA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27850 nadA]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 5.717   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 41 kDa, 5.717   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[safA]]'', ''[[nadC]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[safA]]'', ''[[nadC]]''
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14745&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU27850 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU27850 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU27850 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:nadA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:nadA_context.gif]]

Revision as of 13:28, 13 May 2013

  • Description: quinolinate synthetase

Gene name nadA
Synonyms
Essential no
Product quinolinate synthetase
Function NAD biosynthesis
Gene expression levels in SubtiExpress: nadA
MW, pI 41 kDa, 5.717
Gene length, protein length 1104 bp, 368 aa
Immediate neighbours safA, nadC
Sequences Protein DNA Advanced_DNA
Genetic context
NadA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NadA expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

NadR regulon

The gene

Basic information

  • Locus tag: BSU27850

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate (according to Swiss-Prot)
  • Protein family: Type 3 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Alessandra Albertini, University of Pavia, Italy homepage

Your additional remarks

References