Difference between revisions of "FolE2"
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| − | + | * '''Description:''' GTP cyclohydrolase IB, replaces [[FolE]] under conditions of zinc starvation<br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of folate | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 7.831 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 34 kDa, 7.831 | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:yciA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yciA_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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* '''Operon:''' ''[[folE2]]-[[yciB]]-[[yciC]]'' {{PubMed|9811636}} | * '''Operon:''' ''[[folE2]]-[[yciB]]-[[yciC]]'' {{PubMed|9811636}} | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12426338}} |
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* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 09:28, 7 August 2012
- Description: GTP cyclohydrolase IB, replaces FolE under conditions of zinc starvation
| Gene name | folE2 |
| Synonyms | yciA |
| Essential | no |
| Product | zinc-independent GTP cyclohydrolase IB |
| Function | biosynthesis of folate |
| MW, pI | 34 kDa, 7.831 |
| Gene length, protein length | 915 bp, 305 aa |
| Immediate neighbours | nasA, yciB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU03340
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)
- Protein family: GTP cyclohydrolase IV family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): activated by a variety of divalent cations PubMed
- Effectors of protein activity:
- Interactions: homotetrameric PubMed
Database entries
- UniProt: P94398
- KEGG entry: [3]
- E.C. number: 3.5.4.16
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
