Difference between revisions of "RocR"

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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=rocR_4145747_4147132_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:rocR_expression.png|500px]]
 
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Revision as of 13:00, 23 April 2012

Gene name rocR
Synonyms
Essential no
Product transcriptional activator
Function transcriptional activator of arginine utilization operons
Interactions involving this protein in SubtInteract: RocR
Metabolic function and regulation of this protein in SubtiPathways:
Ammonium/ glutamate
MW, pI 52.6 kDa, 6.08
Gene length, protein length 1383 bp, 461 amino acids
Immediate neighbours rocD, yyxA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
RocR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RocR expression.png





























Categories containing this gene/protein

utilization of amino acids, transcription factors and their control

This gene is a member of the following regulons

The RocR regulon

The gene

Basic information

  • Locus tag: BSU40350

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activation at SigL-dependent promoters of rocABC, rocDEF, and rocG
  • Protein family: Sigma-54 interacting transcription activator
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • Sigma-54 factor interaction domain (143–372)
    • 2x nucleotid-binding domain (171–178),(233–242)
    • HTH motif (434–453)
  • Modification:
  • Cofactor(s): ornithine or citrulline are required for RocR-dependent transcription activation PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon: rocR (according to DBTBS)
  • Regulatory mechanism: autorepression
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • Antibody:

Labs working on this gene/protein

Michel Debarbouille, Pasteur Institute, Paris, France Homepage

Your additional remarks

References