Difference between revisions of "SirA"
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* '''Operon:''' ''[[sirA]]-[[yneF]]'' {{PubMed|9068642}} | * '''Operon:''' ''[[sirA]]-[[yneF]]'' {{PubMed|9068642}} | ||
| − | * '''[ | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yneE_1922017_1922463_1 sirA] {{PubMed|22383849}} |
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| + | * '''Sigma factor:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
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** [[Spo0A]]: transcription activation {{PubMed|14651647,19329632}} | ** [[Spo0A]]: transcription activation {{PubMed|14651647,19329632}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 09:48, 13 April 2012
- Description: sporulation protein, inhibits DNA replication
| Gene name | sirA |
| Synonyms | yneE, yoxF |
| Essential | no |
| Product | inhibitor of DNA replication |
| Function | control of chromosome copy number |
| Interactions involving this protein in SubtInteract: SirA | |
| MW, pI | 17 kDa, 7.353 |
| Gene length, protein length | 444 bp, 148 aa |
| Immediate neighbours | tkt, yneF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
yneE was renamed to sirA.
Basic information
- Locus tag: BSU17900
Phenotypes of a mutant
"over-replication" during sporulation PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: interacts with DnaA and displaces it from the replication origin, resulting in inhibition of replication PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P45707
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
sirA (sporulation inhibitor of replication) is activated by Spo0A~P and inhibits DNA replication during sporulation.
References
Reviews
Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337]
[WorldCat.org]
[DOI]
(I p)
Original publications
