Difference between revisions of "NadC"

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m (Reverted edits by 134.76.70.252 (talk) to last revision by Jstuelk)
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* '''Operon:''' ''[[nadB]]-[[nadC]]-[[nadA]]'' {{PubMed|8444804}}  
 
* '''Operon:''' ''[[nadB]]-[[nadC]]-[[nadA]]'' {{PubMed|8444804}}  
  
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8444804}}  
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=nadC_2847048_2847917_-1 nadC] {{PubMed|22383849}}
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* '''Sigma factor:''' [[SigA]] {{PubMed|8444804}}  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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** [[NadR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16199587 PubMed]
 
** [[NadR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16199587 PubMed]
  
* '''Additional information:'''  
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* '''Additional information:'''
  
 
=Biological materials =
 
=Biological materials =

Revision as of 14:17, 16 April 2012

  • Description: nicotinate-nucleotide diphosphorylase (carboxylating)

Gene name nadC
Synonyms yrxB
Essential no
Product nicotinate-nucleotide diphosphorylase (carboxylating)
Function NAD biosynthesis
MW, pI 31 kDa, 5.18
Gene length, protein length 867 bp, 289 aa
Immediate neighbours nadA, nadB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
NadC context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

NadR regulon

The gene

Basic information

  • Locus tag: BSU27860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: nadC/modD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References