Difference between revisions of "Tpi"

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(The gene)
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* '''Description:''' catalyzes the transformation of glycerinaldehyd 3-phosphate to dihydroxyactonphosphate and the reverse reaktion <br/><br/>
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* '''Description:''' triose phosphate isomerase, glycolytic/ gluconeogenic enzyme<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || yes
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || Triosephosphate isomerase
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|style="background:#ABCDEF;" align="center"| '''Product''' || triosephosphate isomerase
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || isomerase
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|style="background:#ABCDEF;" align="center"|'''Function''' || enzyme in glycolysis/ gluconeogenesis
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26,9 kDa, 4.79
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26,9 kDa, 4.79

Revision as of 12:54, 13 January 2009

  • Description: triose phosphate isomerase, glycolytic/ gluconeogenic enzyme

Gene name tpi
Synonyms tpiA
Essential yes
Product triosephosphate isomerase
Function enzyme in glycolysis/ gluconeogenesis
MW, pI 26,9 kDa, 4.79
Gene length, protein length 759 bp, 253 amino acids
Immediate neighbours pgk, pgm
Gene sequence (+200bp) Protein sequence
Genetic context
Tpi context.gif












The gene

Basic information

  • Coordinates: 3478439 - 3479197

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-glyceraldehyde 3-phosphate = glycerone phosphate
  • Protein family: triosephosphate isomerase family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation (STY) PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions: Pgm-TpiA
  • Localization: cytoplasm PubMed

Database entries

  • Structure: complex with 2-phosphpoglycolic acid, Geobacillus stearothermophilus NCBI
  • Swiss prot entry: [3]
  • KEGG entry: [4]
  • E.C. number: [5]

Additional information

Expression and regulation

  • Regulation: neg. regulated by CggR PubMed, induced by sugar
  • Additional information:

Biological materials

Labs working on this gene/protein

Your additional remarks

References

  1. Ludwig, H., Homuth, G., Schmalisch, M., Dyka, F. M., Hecker, M., and Stülke, J. (2001) Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon. Mol Microbiol 41, 409-422.PubMed