G-box

The G-box element is a riboswitch that controls different genes of purine nucleotide metabolism in response to the presence of guanine.

Genes controlled by a G-box element:

• xpt-pbuX
• nupG
• pbuG
• purE-purK-purB-purC-purS-purQ-purL-purF-purM-purN-purH-purD

Structure of a G-box riboswitch

• 2XO1 PubMed

References

F Sochor, R Silvers, D Müller, C Richter, B Fürtig, H Schwalbe
(19)F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy.
J Biomol NMR: 2016, 64(1);63-74
[PubMed:26704707] [WorldCat.org] [DOI] (I p)

Janina Buck, Anna Wacker, Eberhart Warkentin, Jens Wöhnert, Julia Wirmer-Bartoschek, Harald Schwalbe
Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain.
Nucleic Acids Res: 2011, 39(22);9768-78
[PubMed:21890900] [WorldCat.org] [DOI] (I p)

Peter Daldrop, Francis E Reyes, David A Robinson, Colin M Hammond, David M Lilley, Robert T Batey, Ruth Brenk
Novel ligands for a purine riboswitch discovered by RNA-ligand docking.
Chem Biol: 2011, 18(3);324-35
[PubMed:21439477] [WorldCat.org] [DOI] (I p)

Otmar M Ottink, Ivo M Westerweele, Marco Tesssari, Frank H T Nelissen, Hans A Heus, Sybren S Wijmenga
1H and 13C resonance assignments of a guanine sensing riboswitch's terminator hairpin.
Biomol NMR Assign: 2010, 4(1);89-91
[PubMed:20204714] [WorldCat.org] [DOI] (I p)

Janina Buck, Jonas Noeske, Jens Wöhnert, Harald Schwalbe
Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain.
Nucleic Acids Res: 2010, 38(12);4143-53
[PubMed:20200045] [WorldCat.org] [DOI] (I p)

Vanessa Delfosse, Patricia Bouchard, Eric Bonneau, Pierre Dagenais, Jean-François Lemay, Daniel A Lafontaine, Pascale Legault
Riboswitch structure: an internal residue mimicking the purine ligand.
Nucleic Acids Res: 2010, 38(6);2057-68
[PubMed:20022916] [WorldCat.org] [DOI] (I p)

Jane N Kim, Kenneth F Blount, Izabela Puskarz, Jinsoo Lim, Kristian H Link, Ronald R Breaker
Design and antimicrobial action of purine analogues that bind Guanine riboswitches.
ACS Chem Biol: 2009, 4(11);915-27
[PubMed:19739679] [WorldCat.org] [DOI] (I p)

Oksana Prychyna, Michael S Dahabieh, Jay Chao, Melanie A O'Neill
Sequence-dependent folding and unfolding of ligand-bound purine riboswitches.
Biopolymers: 2009, 91(11);953-65
[PubMed:19603494] [WorldCat.org] [DOI] (P p)

Jane N Kim, Ronald R Breaker
Purine sensing by riboswitches.
Biol Cell: 2008, 100(1);1-11
[PubMed:18072940] [WorldCat.org] [DOI] (I p)

Maumita Mandal, Benjamin Boese, Jeffrey E Barrick, Wade C Winkler, Ronald R Breaker
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria.
Cell: 2003, 113(5);577-86
[PubMed:12787499] [WorldCat.org] [DOI] (P p)

See also:

• RNA switch