ComGD

• Description: DNA transport machinery, minor pseudopilin
  
  

Gene name	comGD
Synonyms
Essential	no
Product	minor pseudopilin
Function	genetic competence, DNA uptake
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	15 kDa, 9.883
Gene length, protein length	429 bp, 143 aa
Immediate neighbours	comGE, comGC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

genetic competence

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

• Locus tag: BSU24700

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • ComGB-ComGD PubMed
  • ComC-ComGD PubMed

• Localization: cell surface PubMed

Database entries

• Structure:

• UniProt: P25956

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comGA-comGB-comGC-comGD-comGE-comGF-comGG-yqzE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by casamino acids PubMed

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)