YfnI

• Description: polyglycerolphosphate lipoteichoic acid synthase, general stress protein, major secreted protein, required for survival at low temperature (4°C)
  
  

Gene name	yfnI
Synonyms	yetP, ltaSA
Essential	no
Product	minor lipoteichoic acid synthetase
Function	biosynthesis of lipoteichoic acid
MW, pI	73 kDa, 5.951
Gene length, protein length	1917 bp, 639 aa
Immediate neighbours	yetO, yfnH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, general stress proteins (controlled by SigB), cell envelope stress proteins (controlled by SigM, W, X, Y), phosphoproteins

This gene is a member of the following regulons

SigB regulon, SigM regulon

The gene

Basic information

• Locus tag: BSU07260

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LTA synthase family (according to Swiss-Prot)

• Paralogous protein(s): LtaS, YqgS, YvgJ

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on (Thr-311 OR Ser-312) PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: extracellular (signal peptide) PubMed

Database entries

• Structure:

• UniProt: Q797B3

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yfnI (according to DBTBS)

• Sigma factor: SigB PubMed, SigM PubMed

• Regulation: induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • SM-NB (yfnI-spc), available in Anne Galinier's and Boris Görke's labs

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Additional reviews: PubMed

Nathalie T Reichmann, Angelika Gründling
Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes.
FEMS Microbiol Lett: 2011, 319(2);97-105
[PubMed:21388439] [WorldCat.org] [DOI] (I p)