AppC

• Description: oligopeptide ABC transporter (permease)
  
  

Gene name	appC
Synonyms
Essential	no
Product	oligopeptide ABC transporter (permease))
Function	uptake of oligopeptides
Metabolic function and regulation of this protein in SubtiPathways: Alternative nitrogen sources
MW, pI	33 kDa, 9.777
Gene length, protein length	909 bp, 303 aa
Immediate neighbours	appB, yjbA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, utilization of nitrogen sources other than amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, ScoC regulon

The gene

Basic information

• Locus tag: BSU11400

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transmembrane type-1 domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: (AppD-AppF)-(AppB-AppC)-AppA PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: P42063

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: appD-appF-appA-appB-appC PubMed

• Sigma factor:

• Regulation:
  • repressed during exponential growth (ScoC) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • ScoC: transcription repression PubMed
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: