Difference between revisions of "SirA"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[DNA replication]]}}
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= This gene is a member of the following [[regulons]] =
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{{SubtiWiki regulon|[[Spo0A regulon]]}}
  
 
=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[DNA replication]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 20:04, 8 December 2010

  • Description: sporulation protein, inhibits DNA replication

Gene name sirA
Synonyms yneE, yoxF
Essential no
Product inhibitor of DNA replication
Function control of chromosome copy number
MW, pI 17 kDa, 7.353
Gene length, protein length 444 bp, 148 aa
Immediate neighbours tkt, yneF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YneE context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA replication

This gene is a member of the following regulons

Spo0A regulon

The gene

yneE was renamed to sirA.

Basic information

  • Locus tag: BSU17900

Phenotypes of a mutant

"over-replication" during sporulation PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: interacts with DnaA and displaces it from the replication origin, resulting in inhibition of replication PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

sirA (sporulation inhibitor of replication) is activated by Spo0A~P and inhibits DNA replication during sporulation.

References

Reviews

Original publications