Difference between revisions of "RpoB"
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| − | * '''Description:''' RNA polymerase beta subunit <br/><br/> | + | * '''Description:''' [[RNA polymerase]] beta subunit <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed] | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || RNA polymerase beta subunit | + | |style="background:#ABCDEF;" align="center"| '''Product''' || [[RNA polymerase]] beta subunit |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || transcription | |style="background:#ABCDEF;" align="center"|'''Function''' || transcription | ||
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* '''Catalyzed reaction/ biological activity:''' Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) (according to Swiss-Prot) | * '''Catalyzed reaction/ biological activity:''' Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) (according to Swiss-Prot) | ||
| − | * '''Protein family:''' RNA polymerase beta chain family (according to Swiss-Prot) | + | * '''Protein family:''' [[RNA polymerase]] beta chain family (according to Swiss-Prot) |
* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[RpoA]]-[[RpoB]]-[[RpoC]] {{PubMed|10499798}}, [[NusA]]-[[RpoB]] {{PubMed|19680289}} | + | * '''Interactions:''' |
| + | ** [[RpoA]]-[[RpoB]]-[[RpoC]] {{PubMed|10499798}}, [[NusA]]-[[RpoB]] {{PubMed|19680289}} | ||
| + | ** [[SigA]]-([[RpoB]]-[[RpoC]]) {{PubMed|19680289,19735077}}, [[SigB]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigD]]-([[RpoB]]-[[RpoC]]), [[SigE]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigF]]-([[RpoB]]-[[RpoC]]), [[SigG]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigH]]-([[RpoB]]-[[RpoC]]), [[SigI]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigK]]-([[RpoB]]-[[RpoC]]), [[SigL]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigM]]-([[RpoB]]-[[RpoC]]), [[SigV]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigW]]-([[RpoB]]-[[RpoC]]), [[SigX]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[SigY]]-([[RpoB]]-[[RpoC]]), [[SigZ]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[Xpf]]-([[RpoB]]-[[RpoC]]), [[YlaC]]-([[RpoB]]-[[RpoC]]) | ||
| + | ** [[YvrI]]-[[RpoB]] {{PubMed|19940246}}, | ||
* '''Localization:''' membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | * '''Localization:''' membrane associated [http://www.ncbi.nlm.nih.gov/pubmed/18763711 PubMed] | ||
Revision as of 18:16, 21 August 2010
- Description: RNA polymerase beta subunit
| Gene name | rpoB |
| Synonyms | |
| Essential | yes PubMed |
| Product | RNA polymerase beta subunit |
| Function | transcription |
| MW, pI | 133 kDa, 4.731 |
| Gene length, protein length | 3579 bp, 1193 aa |
| Immediate neighbours | ybxB, rpoC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU01070
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) (according to Swiss-Prot)
- Protein family: RNA polymerase beta chain family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- RpoA-RpoB-RpoC PubMed, NusA-RpoB PubMed
- SigA-(RpoB-RpoC) PubMed, SigB-(RpoB-RpoC)
- SigD-(RpoB-RpoC), SigE-(RpoB-RpoC)
- SigF-(RpoB-RpoC), SigG-(RpoB-RpoC)
- SigH-(RpoB-RpoC), SigI-(RpoB-RpoC)
- SigK-(RpoB-RpoC), SigL-(RpoB-RpoC)
- SigM-(RpoB-RpoC), SigV-(RpoB-RpoC)
- SigW-(RpoB-RpoC), SigX-(RpoB-RpoC)
- SigY-(RpoB-RpoC), SigZ-(RpoB-RpoC)
- Xpf-(RpoB-RpoC), YlaC-(RpoB-RpoC)
- YvrI-RpoB PubMed,
- Localization: membrane associated PubMed
Database entries
- Structure:
- UniProt: P37870
- KEGG entry: [3]
- E.C. number: 2.7.7.6
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and regulation
- Operon: rpoB DBTBS
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
