Difference between revisions of "SigI"
| Line 78: | Line 78: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[RsgI]]-[[SigI]], the interaction inhibits SigI activity [http://www.ncbi.nlm.nih.gov/sites/entrez/17185538 PubMed] | + | * '''Interactions:''' [[RsgI]]-[[SigI]], the interaction inhibits SigI activity [http://www.ncbi.nlm.nih.gov/sites/entrez/17185538 PubMed], [[SigI]]-[[RpoB]]-[[RpoC]] |
* '''Localization:''' | * '''Localization:''' | ||
| Line 93: | Line 93: | ||
=== Additional information=== | === Additional information=== | ||
| − | + | overexpression of SigI suppresses ''[[mreB]] [[mreBH]] [[mbl]]'' mutants {{PubMed|19114499}} | |
=Expression and regulation= | =Expression and regulation= | ||
| Line 126: | Line 126: | ||
=References= | =References= | ||
| − | <pubmed>19114499,17185538, | + | <pubmed>19114499,17185538,11157964 18156261, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:21, 17 June 2010
- Description: RNA polymerase ECF sigma factor SigI
| Gene name | sigI |
| Synonyms | ykoZ |
| Essential | no |
| Product | RNA polymerase ECF sigma factor SigI |
| Function | control of a class of heat shock genes |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 29 kDa, 8.306 |
| Gene length, protein length | 753 bp, 251 aa |
| Immediate neighbours | ykoY, rsgI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU13450
Phenotypes of a mutant
temperature-sensitive growth on agar plates PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Members of the SigI regulon
gsiB PubMed, mreBH, bcrC PubMed
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: O31654
- KEGG entry: [3]
- E.C. number:
Additional information
overexpression of SigI suppresses mreB mreBH mbl mutants PubMed
Expression and regulation
- Regulation: induced by heat PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Kathrin Schirner, Jeff Errington
The cell wall regulator {sigma}I specifically suppresses the lethal phenotype of mbl mutants in Bacillus subtilis.
J Bacteriol: 2009, 191(5);1404-13
[PubMed:19114499]
[WorldCat.org]
[DOI]
(I p)
Chi-Ling Tseng, Gwo-Chyuan Shaw
Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis.
J Bacteriol: 2008, 190(5);1561-7
[PubMed:18156261]
[WorldCat.org]
[DOI]
(I p)
Kei Asai, Takafumi Ootsuji, Kazue Obata, Takashi Matsumoto, Yasutaro Fujita, Yoshito Sadaie
Regulatory role of RsgI in sigI expression in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 1);92-101
[PubMed:17185538]
[WorldCat.org]
[DOI]
(P p)
U Zuber, K Drzewiecki, M Hecker
Putative sigma factor SigI (YkoZ) of Bacillus subtilis is induced by heat shock.
J Bacteriol: 2001, 183(4);1472-5
[PubMed:11157964]
[WorldCat.org]
[DOI]
(P p)
