Difference between revisions of "ComS"
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[srfAA]]-[[srfAB]]-[[comS]]-[[srfAC]]-[[srfAD]]'' {{PubMed|1715856}} |
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|1715856}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ||
| + | ** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ||
| + | ** [[ComA]]: transcription activation {{PubMed|1715856}} | ||
| + | ** [[PerR]]: transcription activation {{PubMed|16166527}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
| Line 121: | Line 126: | ||
<pubmed> 19609260 </pubmed> | <pubmed> 19609260 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>17560370,10447896,,9000055, 10361283, 10447896, 11703662 </pubmed> | + | <pubmed>17560370,10447896,,9000055, 10361283, 10447896, 11703662 1715856</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:45, 19 August 2009
- Description: antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway
| Gene name | comS |
| Synonyms | |
| Essential | no |
| Product | antiadaptor protein (anti-MecA) |
| Function | control of ComK degradation |
| MW, pI | 5 kDa, 9.145 |
| Gene length, protein length | 138 bp, 46 aa |
| Immediate neighbours | srfAB, srfAC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU03500
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: P80355
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260]
[WorldCat.org]
[DOI]
(I p)
Original Publications
