Difference between revisions of "T-box"

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The T-box element is an [[RNA switch]] that controls genes involved in amino acid metabolism.
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In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA  of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
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==Complete list of genes controlled by T-box elements==
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* Induction by alanine limitation
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** ''[[alaS]]''
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* Induction by aspartate limitation
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** ''[[hisS]]-[[aspS]]''
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* Induction by cysteine limitation
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** ''[[cysE]]-[[cysS]]-[[mrnC]]-[[yacO]]-[[yacP]]''
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* Induction by glycine limitation
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** ''[[glyA]], [[glyQ]]-[[glyS]]''
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* Induction by histidine limitation
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** ''[[hisS]]-[[aspS]]''
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* Induction by isoleucine limitation
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** ''[[ileS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]''
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* Induction by leucine limitation
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** ''[[leuS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'', ''[[yvbW]]''
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* Induction by phenyalanine limitation
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** ''[[pheS]]-[[pheT]]''
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* Induction by proline limitation
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** ''[[proB]]-[[proA]]'', ''[[proI]]''
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* Induction by serine limitation
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** ''[[serS]]''
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* Induction by threonine limitation
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** ''[[thrS]], [[thrZ]]-[[ywhA]]''
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* Induction by tryptophan limitation
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** ''[[rtpA]]-[[ycbK]]'', ''[[trpS]]''
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* Induction by tyrosine limitation
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** ''[[tyrS]], [[tyrZ]]''
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* Induction by valine limitation
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** ''[[valS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]''
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==Structure of a T-box ribowsitch==
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<pubmed>28621923 12547201 31740854  </pubmed>
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==Reviews on T-box regulation==
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<pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903  24816551  32882008</pubmed>
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=See also:=
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* [[RNA switch]]
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=Back to [[regulons]]=

Latest revision as of 08:40, 5 January 2021

The T-box element is an RNA switch that controls genes involved in amino acid metabolism.

In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.

Complete list of genes controlled by T-box elements

  • Induction by alanine limitation
  • Induction by aspartate limitation
  • Induction by histidine limitation
  • Induction by phenyalanine limitation
  • Induction by serine limitation
  • Induction by tyrosine limitation

Structure of a T-box ribowsitch

Shuang Li, Zhaoming Su, Jean Lehmann, Vassiliki Stamatopoulou, Nikoleta Giarimoglou, Frances E Henderson, Lixin Fan, Grigore D Pintilie, Kaiming Zhang, Muyuan Chen, Steven J Ludtke, Yun-Xing Wang, Constantinos Stathopoulos, Wah Chiu, Jinwei Zhang
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions.
Nat Struct Mol Biol: 2019, 26(12);1094-1105
[PubMed:31740854] [WorldCat.org] [DOI] (I p)

Xianyang Fang, Malgorzata Michnicka, Yikan Zhang, Yun-Xing Wang, Edward P Nikonowicz
Capture and Release of tRNA by the T-Loop Receptor in the Function of the T-Box Riboswitch.
Biochemistry: 2017, 56(28);3549-3558
[PubMed:28621923] [WorldCat.org] [DOI] (I p)

Melinda S Gerdeman, Tina M Henkin, Jennifer V Hines
Solution structure of the Bacillus subtilis T-box antiterminator RNA: seven nucleotide bulge characterized by stacking and flexibility.
J Mol Biol: 2003, 326(1);189-201
[PubMed:12547201] [WorldCat.org] [DOI] (P p)


Reviews on T-box regulation


See also:

Back to regulons