AbrB

• Description: transition state regulator
  
  

Gene name	abrB
Synonyms	cpsX
Essential
Product	transcriptional regulator
Function	regulation of transition state genes
MW, pI	10 kDa, 6.57
Gene length, protein length	288 bp, 96 aa
Immediate neighbours
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): Abh

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: interaction with AbbA results in inactivation of AbrB PubMed

• Interactions: AbrB-AbbA PubMed

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry:

• E.C. number:

Additional information

negative regulation of abrB, aprE, ftsAZ, kinC, motA, nprE, pbpE, rbs, spo0H, spoVG, spo0E, tycA, sbo-alb, yqxM-sipW-tasA; positive regulation of comK, hpr

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: expressed at the onset of staionary phase

• Regulatory mechanism: repressed by Spo0A-P

• Additional information:

Biological materials

• Mutant: TT731 (aphA3)

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Richard Losick, Harvard Univ., Cambridge, USA homepage

Mark Strauch, Baltimore, USA homepage

References

1. Banse et al. (2008) Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis.Proc. Natl. Acad. Sci. USA 105: 15547-15552. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed