Difference between revisions of "T-box"

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The T-box element is a [[RNA switch]] that controls genes involved in amino acid metabolism.
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The T-box element is an [[RNA switch]] that controls genes involved in amino acid metabolism.
  
 
In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA  of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
 
In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA  of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.
  
==Genes controlled by T-box elements==
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==Complete list of genes controlled by T-box elements==
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* Induction by alanine limitation
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** ''[[alaS]]''
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* Induction by aspartate limitation
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** ''[[hisS]]-[[aspS]]''
  
 
* Induction by cysteine limitation
 
* Induction by cysteine limitation
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** ''[[cysE]]-[[cysS]]-[[mrnC]]-[[yacO]]-[[yacP]]''
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* Induction by glycine limitation
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** ''[[glyA]], [[glyQ]]-[[glyS]]''
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* Induction by histidine limitation
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** ''[[hisS]]-[[aspS]]''
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* Induction by isoleucine limitation
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** ''[[ileS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]''
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* Induction by leucine limitation
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** ''[[leuS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]'', ''[[yvbW]]''
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* Induction by phenyalanine limitation
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** ''[[pheS]]-[[pheT]]''
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* Induction by proline limitation
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** ''[[proB]]-[[proA]]'', ''[[proI]]''
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* Induction by serine limitation
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** ''[[serS]]''
  
** [[cysE]]-[[cysS]]-[[mrnC]]-[[yacO]]-[[yacP]]''  
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* Induction by threonine limitation
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** ''[[thrS]], [[thrZ]]-[[ywhA]]''
  
 
* Induction by tryptophan limitation
 
* Induction by tryptophan limitation
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** ''[[rtpA]]-[[ycbK]]'', ''[[trpS]]''
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* Induction by tyrosine limitation
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** ''[[tyrS]], [[tyrZ]]''
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* Induction by valine limitation
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** ''[[valS]]'', ''[[ilvB]]-[[ilvH]]-[[ilvC]]-[[leuA]]-[[leuA]]-[[leuC]]-[[leuD]]''
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==Structure of a T-box ribowsitch==
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<pubmed>28621923 12547201 31740854  </pubmed>
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==Reviews on T-box regulation==
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<pubmed> 19258532,7527891, 11917026 ,8348614,17381302 10546897 19932103 18625071 24954903  24816551  32882008</pubmed>
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=See also:=
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* [[RNA switch]]
  
** ''[[rtpA]]-[[ycbK]]''
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=Back to [[regulons]]=

Latest revision as of 08:40, 5 January 2021

The T-box element is an RNA switch that controls genes involved in amino acid metabolism.

In the absence of an amino acid, the uncharged tRNA binds the T-box region in the leader region of the mRNA of the controlled gene/ operon and thereby prevents the formation of a transcription terminator. The result is gene expression of the target gene in the absence of the specific amino acid.

Complete list of genes controlled by T-box elements

  • Induction by alanine limitation
  • Induction by aspartate limitation
  • Induction by histidine limitation
  • Induction by phenyalanine limitation
  • Induction by serine limitation
  • Induction by tyrosine limitation

Structure of a T-box ribowsitch

Shuang Li, Zhaoming Su, Jean Lehmann, Vassiliki Stamatopoulou, Nikoleta Giarimoglou, Frances E Henderson, Lixin Fan, Grigore D Pintilie, Kaiming Zhang, Muyuan Chen, Steven J Ludtke, Yun-Xing Wang, Constantinos Stathopoulos, Wah Chiu, Jinwei Zhang
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions.
Nat Struct Mol Biol: 2019, 26(12);1094-1105
[PubMed:31740854] [WorldCat.org] [DOI] (I p)

Xianyang Fang, Malgorzata Michnicka, Yikan Zhang, Yun-Xing Wang, Edward P Nikonowicz
Capture and Release of tRNA by the T-Loop Receptor in the Function of the T-Box Riboswitch.
Biochemistry: 2017, 56(28);3549-3558
[PubMed:28621923] [WorldCat.org] [DOI] (I p)

Melinda S Gerdeman, Tina M Henkin, Jennifer V Hines
Solution structure of the Bacillus subtilis T-box antiterminator RNA: seven nucleotide bulge characterized by stacking and flexibility.
J Mol Biol: 2003, 326(1);189-201
[PubMed:12547201] [WorldCat.org] [DOI] (P p)


Reviews on T-box regulation


See also:

Back to regulons