ImmR

• Description: transcriptional repressor (Xre family), controls expression of genes of the mobile genetic element ICEBs1, induction by the SOS response or the RapI-PhrI sensory system
  
  

Gene name	immR
Synonyms	ydcN
Essential	no
Product	transcriptional repressor (Xre family)
Function	control of transfer of the mobile genetic element ICEBs1
Gene expression levels in SubtiExpress: immR
Interactions involving this protein in SubtInteract: ImmR
MW, pI	14 kDa, 4.989
Gene length, protein length	381 bp, 127 aa
Immediate neighbours	immA, xis
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, mobile genetic elements

The ImmR regulon:

• xis

The gene

Basic information

• Locus tag: BSU04820

Database entries

• BsubCyc: BSU04820

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Xre family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity: binding of RapI to ImmR results in loss of DNA-binding activity of ImmR and subsequently in induction of ImmR-repressed genes PubMed

• Interactions:
  • ImmA-ImmR PubMed
  • RapI-ImmR PubMed

• Localization:

Database entries

• BsubCyc: BSU04820

• Structure:

• UniProt: P96631

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: immR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: ImmR is degraded by the anti-repressor ImmA PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 265 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 65 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Baundauna Bose, Alan D Grossman
Regulation of horizontal gene transfer in Bacillus subtilis by activation of a conserved site-specific protease.
J Bacteriol: 2011, 193(1);22-9
[PubMed:21036995] [WorldCat.org] [DOI] (I p)

Baundauna Bose, Jennifer M Auchtung, Catherine A Lee, Alan D Grossman
A conserved anti-repressor controls horizontal gene transfer by proteolysis.
Mol Microbiol: 2008, 70(3);570-82
[PubMed:18761623] [WorldCat.org] [DOI] (I p)

Jennifer M Auchtung, Catherine A Lee, Katherine L Garrison, Alan D Grossman
Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis.
Mol Microbiol: 2007, 64(6);1515-28
[PubMed:17511812] [WorldCat.org] [DOI] (P p)