PdxK

• Description: pyridoxine, pyridoxal, and pyridoxamine kinase
  
  

Gene name	pdxK
Synonyms	ywdB, ipa-52r, thiD
Essential	no
Product	pyridoxine, pyridoxal, and pyridoxamine kinase
Function	biosynthesis of pyridoxal phosphate
Gene expression levels in SubtiExpress: pdxK
Metabolic function and regulation of this protein in SubtiPathways: PdxK
MW, pI	28 kDa, 4.922
Gene length, protein length	813 bp, 271 aa
Immediate neighbours	ywzG, ywdA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU38020

Database entries

• BsubCyc: BSU38020

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine (according to Swiss-Prot)

• Protein family: thiD family (according to Swiss-Prot)

• Paralogous protein(s): ThiD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU38020

• Structure: 2IB5

• UniProt: P39610

• KEGG entry: [3]

• E.C. number: 2.7.4.7

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

• Operon: pdxK PubMed

• Expression browser: pdxK PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 1170 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 2207 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: