BdbC

• Description: thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins
  
  

Gene name	bdbC
Synonyms	yvgU
Essential	no
Product	thiol-disulfide oxidoreductase
Function	oxidative folding of proteins
Gene expression levels in SubtiExpress: bdbC
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	15 kDa, 9.054
Gene length, protein length	414 bp, 138 aa
Immediate neighbours	yvgT, bdbD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, chaperones/ protein folding, sporulation proteins, membrane proteins

This gene is a member of the following regulons

ComK regulon, SigE regulon

The gene

Basic information

• Locus tag: BSU33470

Phenotypes of a mutant

• loss of transformability PubMed
• sensitive to osmotic shock PubMed
• several proteins are absent from the membrane proteome of a bdbC-bdbD mutant: PubMed
  • the membrane proteins BglP, TcyP, SipU, LytA, and YxaI PubMed
  • the cytoplasmic or membrane-associated proteins GlkX, ProA, PyrAA, PyrAB, PyrH, PyrE, PyrF, DegS, YbxA PubMed

Database entries

• BsubCyc: BSU33470

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • formation of thiol disulfide bonds in ComEC and ComGC (together with BdbD) PubMed
  • oxidative folding of SunA (together with BdbB)

• Protein family: BdbC subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33470

• Structure:

• UniProt: O32217

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: bdbD-bdbC PubMed

• Expression browser: bdbC PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed early during sporulation in the mother cell (SigE) PubMed

• Regulatory mechanism:
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: