Difference between revisions of "EfeB"

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(Original publications)
(Original publications)
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<pubmed> 24140208 </pubmed>
 
<pubmed> 24140208 </pubmed>
 
== Original publications ==
 
== Original publications ==
<pubmed>16672620,19180538,12354229, 19383693 9353933 9683469 15554971 21479178 18179421 22923395 23180473 23560556 23764491 23820555 24620988 </pubmed>
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<pubmed>16672620,19180538,12354229, 19383693 9353933 9683469 15554971 21479178 18179421 22923395 23180473 23560556 23764491 23820555 24620988 18931290 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 08:41, 14 March 2014

  • Description: elemental iron uptake system, heme peroxidase, converts ferrous iron (Fe(II) to ferric iron (FeIII)) for uptake by EfeO-EfeU, peroxide detoxification under microaerobic conditions

Gene name efeB
Synonyms ipa-29d, ywbN
Essential no
Product heme peroxidase in elemental iron uptake
Function ferrous iron conversion
Gene expression levels in SubtiExpress: efeB
Interactions involving this protein in SubtInteract: EfeB
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 45 kDa, 8.64
Gene length, protein length 1248 bp, 416 aa
Immediate neighbours ywbO, efeO
Sequences Protein DNA DNA_with_flanks
Genetic context
YwbN context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YwbN expression.png















Categories containing this gene/protein

acquisition of iron, iron metabolism, cell envelope stress proteins (controlled by SigM, V, W, X, Y), resistance against oxidative and electrophile stress, membrane proteins

This gene is a member of the following regulons

Fur regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

  • Locus tag: BSU38260

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • oxidizes ferrous iron to ferric iron for uptake by EfeO-EfeU PubMed
    • eliminates reactive oxygen species that accumulate in the presence of ferrous iron PubMed
    • peroxide detoxification under microaerobic conditions PubMed
  • Protein family: DyP-type peroxidase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:
    • activity is increased in the presence of EfeO due to the displacement of ferric iron PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

Your additional remarks

References

Reviews

Vivianne J Goosens, Carmine G Monteferrante, Jan Maarten van Dijl
The Tat system of Gram-positive bacteria.
Biochim Biophys Acta: 2014, 1843(8);1698-706
[PubMed:24140208] [WorldCat.org] [DOI] (P p)

Original publications