Stringent response

Regulator	stringent response
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

Genes in this regulon

Negative regulation

• adk
• atpI-atpB-atpE-atpF-atpH-atpA-atpG-atpD-atpC
• cymR-yrvO-trmU
• dltA-dltB-dltC-dltD-dltE
• dxs
• frr
• fusA
• gcaD-prs
• infA
• infC-rpmI-rplT
• map
• mbl
• murE
• nusB
• pdhA-pdhB-pdhC-pdhD
• pnpA
• ptsG-ptsH-ptsI
• pyrH
• qoxA-qoxB-qoxC-qoxD
• rnc
• rplA
• rplJ
• rplK
• rplL
• rplM
• rplQ
• rplS
• rplU
• rpmB
• rpmE
• rpmF
• rpmJ
• rpoA
• rpoB
• rpoC
• rpsB
• rpsD
• rpsF-ssbA-rpsR
• rpsG
• rpsI
• rpsJ-rplC-rplD-rplW-rplB-rpsS-rplV-rpsC-rplP-rpmC-rpsQ-rplN-rplX-rplE-rpsN-rpsH-rplF-rplR-rpsE-rpmD-rplO
• rpsK
• rpsL
• rpsM
• rpsO
• rpsP
• scpA-scpB
• secY
• tig
• truA
• tsf
• tufA
• ybxB
• ybxF
• yjlC-ndh
• ylaG
• ylbN
• ylxS-nusA-ylxR-ylxQ-infB-ylxP-rbfA
• yrvE
• ysxB
• yugI

Positive regulation

• alsS-alsD
• pycA

Key original publications

Shigeo Tojo, Kanako Kumamoto, Kazutake Hirooka, Yasutaro Fujita
Heavy involvement of stringent transcription control depending on the adenine or guanine species of the transcription initiation site in glucose and pyruvate metabolism in Bacillus subtilis.
J Bacteriol: 2010, 192(6);1573-85
[PubMed:20081037] [WorldCat.org] [DOI] (I p)

Libor Krásný, Hana Tiserová, Jirí Jonák, Dominik Rejman, Hana Sanderová
The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis.
Mol Microbiol: 2008, 69(1);42-54
[PubMed:18433449] [WorldCat.org] [DOI] (I p)

Christine Eymann, Georg Homuth, Christian Scharf, Michael Hecker
Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.
J Bacteriol: 2002, 184(9);2500-20
[PubMed:11948165] [WorldCat.org] [DOI] (P p)

T M Wendrich, M A Marahiel
Cloning and characterization of a relA/spoT homologue from Bacillus subtilis.
Mol Microbiol: 1997, 26(1);65-79
[PubMed:9383190] [WorldCat.org] [DOI] (P p)