MenD

• Description: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase
  
  

Gene name	menD
Synonyms
Essential	yes PubMed
Product	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase
Function	biosynthesis of menaquinone
Gene expression levels in SubtiExpress: menD
Metabolic function and regulation of this protein in SubtiPathways: menD
MW, pI	63 kDa, 5.655
Gene length, protein length	1740 bp, 580 aa
Immediate neighbours	ytxM, menF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, essential genes

The gene

Basic information

• Locus tag: BSU30820

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO₂ (according to Swiss-Prot)

• Protein family: MenD subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): thiamine pyrophosphate, divalent metal ion such as Mn(2+)) PubMed

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2X7J PubMed

• UniProt: P23970

• KEGG entry: [3]

• E.C. number: 2.2.1.9

Expression and regulation

• Operon: menF-menD-ytxM-menB-menE-menC PubMed

• Expression browser: menD PubMed

• Sigma factor: SigA: PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: