LctP

• Description: lactate permease, excretion
  
  

Gene name	lctP
Synonyms	ycgC
Essential	no
Product	L-lactate permease
Function	lactate excretion
Gene expression levels in SubtiExpress: lctP
Metabolic function and regulation of this protein in SubtiPathways: lctP
MW, pI	57 kDa, 9.766
Gene length, protein length	1623 bp, 541 aa
Immediate neighbours	ldh, mdr
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, carbon core metabolism, membrane proteins

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

• Locus tag: BSU03060

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: lactate permease family (according to Swiss-Prot)

• Paralogous protein(s): LutP

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P55910

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ldh-lctP PubMed

• Expression browser: lctP PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced under anaerobic conditions (Rex) PubMed

• Regulatory mechanism:
  • Rex: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

You-Kwan Oh, Bernhard O Palsson, Sung M Park, Christophe H Schilling, Radhakrishnan Mahadevan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
J Biol Chem: 2007, 282(39);28791-28799
[PubMed:17573341] [WorldCat.org] [DOI] (P p)

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, T Hoffmann, M Marino, H Nedjari, E Presecan-Siedel, O Dreesen, P Glaser, D Jahn
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression.
J Bacteriol: 2000, 182(11);3072-80
[PubMed:10809684] [WorldCat.org] [DOI] (P p)