Difference between revisions of "PgcA"

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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
 
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* the inactivation of ''[[pgcA]]'' suppresses the poor and filametous growth of the ''[[yvcL]] [[zapA]]'' double mutant {{PubMed|24097947}}
 
=== Database entries ===
 
=== Database entries ===
  
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
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* '''[[Domains]]:'''  
  
 
* '''Modification:''' phosphorylated on ser/ thr/ tyr [http://www.ncbi.nlm.nih.gov/pubmed/16493705 PubMed], [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]   
 
* '''Modification:''' phosphorylated on ser/ thr/ tyr [http://www.ncbi.nlm.nih.gov/pubmed/16493705 PubMed], [http://www.ncbi.nlm.nih.gov/pubmed/17726680 PubMed]   
  
* '''Cofactor(s):'''
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* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pgcA_1006774_1008519_1 pgcA] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pgcA_1006774_1008519_1 pgcA] {{PubMed|22383849}}
  
* '''Sigma factor:'''  
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* '''[[Sigma factor]]:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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<pubmed>20735481 </pubmed>
 
<pubmed>20735481 </pubmed>
 
==Original publications==
 
==Original publications==
'''Additional publications:''' {{PubMed|22396664}}
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<pubmed>,15175311,17726680 16493705, 15640167 17662947 22396664 24097947</pubmed>
<pubmed>,15175311,17726680 16493705, 15640167 17662947 </pubmed>
 
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:17, 21 December 2013

  • Description: alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)

Gene name pgcA
Synonyms yhxB, gtaC, gtaE
Essential no
Product alpha-phosphoglucomutase
Function interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate
Gene expression levels in SubtiExpress: pgcA
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 62 kDa, 4.913
Gene length, protein length 1695 bp, 565 aa
Immediate neighbours glpD, yhcY
Sequences Protein DNA DNA_with_flanks
Genetic context
YhxB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PgcA expression.png















Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09310

Phenotypes of a mutant

  • the inactivation of pgcA suppresses the poor and filametous growth of the yvcL zapA double mutant PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)
  • Protein family: phosphohexose mutase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed, PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)

Original publications