Difference between revisions of "NtdA"

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(Original publications)
(The protein)
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* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
 
** pyridoxalphosphate {{PubMed|23586652}}  
 
** pyridoxalphosphate {{PubMed|23586652}}  
  
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* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
 +
** forms dimers {{PubMed|24097983}}
  
 
* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
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=== Database entries ===
 
=== Database entries ===
  
* '''Structure:'''
+
* '''Structure:'''
 +
** [http://www.rcsb.org/pdb/explore/explore.do?pdbId=4K2I 4K2I] {{PubMed|24097983}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O07566 O07566]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/O07566 O07566]

Revision as of 19:59, 12 November 2013

  • Description: pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase

Gene name ntdA
Synonyms yhjL
Essential no
Product pyridoxal phosphate-dependent

3-oxo-glucose-6-phosphate:glutamate aminotransferase

Function synthesis of the antibiotic kanosamine
Gene expression levels in SubtiExpress: ntdA
MW, pI 49 kDa, 5.971
Gene length, protein length 1323 bp, 441 aa
Immediate neighbours ntdB, ntdR
Sequences Protein DNA DNA_with_flanks
Genetic context
YhjL context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NtdA expression.png















Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

NtdR regulon

The gene

Basic information

  • Locus tag: BSU10550

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • 3-oxo-d-glucose-6-phosphate + glutamate --> kanosamine-6-phosphate PubMed
  • Protein family: degT/dnrJ/eryC1 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by 3,3'-neotrehalosadiamine (NtdR) PubMed
  • Regulatory mechanism: NtdR: positive regulator PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications