CtaA

• Description: heme A synthase
  
  

Gene name	ctaA
Synonyms
Essential	no
Product	heme A synthase
Function	heme biosynthesis
Gene expression levels in SubtiExpress: ctaA
MW, pI	33 kDa, 9.644
Gene length, protein length	918 bp, 306 aa
Immediate neighbours	pycA, ctaB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, sporulation proteins, membrane proteins

This gene is a member of the following regulons

ResD regulon, SigE regulon

The gene

Basic information

• Locus tag: BSU14870

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: heme A synthesis from protoheme IX (heme B)

• Protein family: COX15/ctaA family, Type 1 subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • contains 8 transmembrane segments

• Modification:

• Cofactor(s): heme B

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P12946

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ctaA PubMed

• Expression browser: ctaA PubMed

• Sigma factor: SigA PubMed, SigE PubMed

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Lars Hederstedt
Heme A biosynthesis.
Biochim Biophys Acta: 2012, 1817(6);920-7
[PubMed:22484221] [WorldCat.org] [DOI] (P p)